REGENERATION (REG) PROTEINS FOR THE TREATMENT OF DIABETES
Background: Diabetes is a condition which is proposed to affect upwards of 30% or greater of the US population by the year 2020 imposing an extreme economic burden on the healthcare system.
Diabetes market:
Ø Diabetes affects 285 million people worldwide.
Ø 7 million people develop diabetes each year
Ø This number is expected to hit 438 million by 2030
Ø The incidence is increasing due to the aging population, increasing rates of obesity and sedentary lifestyle
Ø Considerable costs for healthcare system and loss of work
Ø People with diabetes incur medical costs that are two to three times higher than those without diabetes. A person with diabetes can face direct costs for medication and supplies ranging from $1,000 to $15,000 a year.
Ø By 2020, it’s estimated that diabetes will cost select healthcare system $16.9 billion a year.
Preclinical data: We have demonstrated that regeneration (Reg) proteins is able to improve diabetes in laboratory animals by regulating their glucose tolerance. We have designed a recombinant form of this protein for future application to clinical trials.
IP: REG protein for use in diabetes - Patent application filed.
References:
Bluth MH, Patel SA, Wu H, Fan Z, Okamato H, Dieckgraefe B, Zenilman ME. Pancreatic
regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis. World Journal of Gastroenterology 2006;12:4511-4516.
Bluth MH, Mueller CM, Pierre J, Callender G, Kandil E, Viterbo D, Fu SL, Sugawara A,
Takasawa S, Okamoto H, Zenilman ME. Pancreatic reg I in chronic pancreatitis and aging: Implications for new therapeutic approaches to diabetes. Pancreas 2008;37:386-395.
Background: Diabetes is a condition which is proposed to affect upwards of 30% or greater of the US population by the year 2020 imposing an extreme economic burden on the healthcare system.
Diabetes market:
Ø Diabetes affects 285 million people worldwide.
Ø 7 million people develop diabetes each year
Ø This number is expected to hit 438 million by 2030
Ø The incidence is increasing due to the aging population, increasing rates of obesity and sedentary lifestyle
Ø Considerable costs for healthcare system and loss of work
Ø People with diabetes incur medical costs that are two to three times higher than those without diabetes. A person with diabetes can face direct costs for medication and supplies ranging from $1,000 to $15,000 a year.
Ø By 2020, it’s estimated that diabetes will cost select healthcare system $16.9 billion a year.
Preclinical data: We have demonstrated that regeneration (Reg) proteins is able to improve diabetes in laboratory animals by regulating their glucose tolerance. We have designed a recombinant form of this protein for future application to clinical trials.
IP: REG protein for use in diabetes - Patent application filed.
References:
Bluth MH, Patel SA, Wu H, Fan Z, Okamato H, Dieckgraefe B, Zenilman ME. Pancreatic
regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis. World Journal of Gastroenterology 2006;12:4511-4516.
Bluth MH, Mueller CM, Pierre J, Callender G, Kandil E, Viterbo D, Fu SL, Sugawara A,
Takasawa S, Okamoto H, Zenilman ME. Pancreatic reg I in chronic pancreatitis and aging: Implications for new therapeutic approaches to diabetes. Pancreas 2008;37:386-395.
